Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS16, BCL2L1, and BTF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus RPS16 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS16 →	-0.280	-0.058	.001	.002	3	6
CCRCC	BCL2L1 →	+0.207	+0.029	.001	.003	3	6
LSCC	BTF3 →	-0.305	-0.060	<.001	<.001	3	6
LSCC	RANBP1 →	-0.415	-0.063	<.001	<.001	3	6
BRCA	RPUSD2_S68 →	-0.374	-0.049	.001	.002	3	5
BRCA	RRP15 →	-0.417	-0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902236 vs RPS16 — GBM

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