Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP295, SRSF3, and USP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus CEP295 in LSCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEP295 →	-0.554	-0.331	<.001	<.001	3	6
LSCC	SRSF3 →	-0.515	-0.280	<.001	.001	3	5
OV	USP1 →	-0.540	-0.132	<.001	.002	3	5
LSCC	CASP8AP2 →	-0.836	-0.404	<.001	<.001	3	5
PDAC	ZC3H14 →	-0.317	-0.222	<.001	<.001	3	5
LSCC	TMEM43 →	-0.483	-0.344	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902236 vs CEP295 — LSCC

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