Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XKR8, ID1, and TSPAN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XKR8 grouped by Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	XKR8 →	+1.180	+1.140	<.001	.003	3	5
BLOOD_Leukemia	ID1 →	+2.234	+0.737	<.001	.001	3	4
BLOOD_Leukemia	TSPAN5 →	+1.636	+0.694	.001	.003	3	4
BLOOD_Leukemia	ZNF792 →	+1.596	+1.066	<.001	.001	3	4
LUNG_NSCLC_LUAD	GABRE →	+2.354	+0.764	.001	.001	3	4
LUNG_NSCLC_LUSC	ACTN4 →	+1.366	+0.374	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XKR8 by Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity — BLOOD_Leukemia

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