Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLMN, CBFA2T2, and TGIF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus CLMN in BONE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CLMN →	+1.622	+0.197	.006	.003	3	6
OVARY	CBFA2T2 →	+0.996	+0.183	.001	.001	2	7
STOMACH	TGIF2 →	+0.846	+0.188	.008	<.001	3	5
BONE	BORCS6 →	-0.995	-0.179	.005	.004	3	5
OVARY	ELMO2 →	+1.076	+0.200	<.001	<.001	3	5
BLOOD_Leukemia	AIFM3 →	+1.424	+0.129	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902236 vs CLMN — BONE

Explore this scatter interactively →