Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC38, RNF213-AS1, and HIGD1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus CCDC38 in GBM (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCDC38 →	+0.196	+0.379	.002	.008	3	3
GBM	RNF213-AS1 →	+0.375	+0.581	.001	<.001	3	3
UCEC	HIGD1A →	-0.599	-0.454	.001	.003	3	3
UCEC	CTSH →	+0.825	+0.369	.002	.006	3	2
CCRCC	BLMH →	+0.217	+0.638	.005	.001	2	3
CCRCC	FIBCD1 →	-0.811	-0.545	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902231 vs CCDC38 — GBM

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