Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNA9, MEGF6, and PGBD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRNA9 grouped by Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CHRNA9 →	+0.204	+0.066	.007	.004	2	5
LUNG_NSCLC_LUSC	MEGF6 →	+0.197	+0.069	.007	<.001	3	4
BLOOD_Leukemia	PGBD3 →	-0.187	-0.070	.005	.005	3	4
BLOOD_Leukemia	EPB41L1 →	-0.194	-0.092	<.001	.001	3	4
KIDNEY	NPM1 →	-0.313	-0.057	<.001	.003	3	4
SKIN	GPR151 →	+0.177	+0.056	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRNA9 by Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity — KIDNEY

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