Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A12, ZC3H13, and SH3BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus SLC25A12 in LUNG_SCLC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC25A12 →	+0.840	+0.343	<.001	<.001	3	5
URINARY_TRACT	ZC3H13 →	+0.624	+0.309	.006	.003	2	6
BLOOD_Leukemia	SH3BP2 →	+1.372	+0.186	.001	.002	3	5
OVARY	PHLDA1 →	+2.472	+0.295	<.001	<.001	3	5
KIDNEY	SLC25A13 →	-1.466	-0.202	.002	.003	3	4
LUNG_SCLC	MRPS31 →	+0.844	+0.275	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902230 vs SLC25A12 — LUNG_SCLC

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