Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPT1, PGAM1, and PSMD11, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus TPT1 in LIVER (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TPT1 →	+2.312	+0.406	.001	.005	3	17
URINARY_TRACT	PGAM1 →	+3.148	+0.322	.005	.008	3	13
OVARY	PSMD11 →	+1.107	+0.316	<.001	<.001	3	12
URINARY_TRACT	PSMC2 →	+1.579	+0.391	<.001	.006	3	12
URINARY_TRACT	PSMD2 →	+1.737	+0.434	<.001	.007	3	12
URINARY_TRACT	PSMD8 →	+1.178	+0.373	.004	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902230 vs TPT1 — LIVER

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