Regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMOD1_S85, RPL5, and TNS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus LMOD1_S85 in CCRCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LMOD1_S85 →	+0.775	+0.031	.002	.001	3	8
OV	RPL5 →	-0.211	-0.042	.004	.003	3	7
OV	TNS2 →	+0.323	+0.039	.004	.002	3	7
COAD	C2 →	+0.518	+0.051	<.001	<.001	3	7
COAD	COL15A1 →	+0.401	+0.045	<.001	<.001	3	7
GBM	EPB41L3 →	+0.639	+0.058	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902229 vs LMOD1_S85 — CCRCC

Explore this scatter interactively →