Regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLR1, TREM1, and LINC02084, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus OLR1 in UCEC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OLR1 →	-0.981	-0.132	<.001	<.001	3	4
LSCC	TREM1 →	-1.061	-0.150	<.001	<.001	3	4
OV	LINC02084 →	+0.529	+0.164	<.001	<.001	3	3
COAD	DUSP26 →	-0.263	-0.092	.005	.005	3	3
COAD	RN7SL594P →	+0.181	+0.119	.006	.009	3	3
COAD	SNX24 →	+0.407	+0.118	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902229 vs OLR1 — UCEC

Explore this scatter interactively →