Regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMB3, LAMA3, and KRT17, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus LAMB3 in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LAMB3 →	+2.920	+0.069	<.001	.002	3	9
URINARY_TRACT	LAMA3 →	+3.159	+0.095	<.001	.002	3	8
STOMACH	KRT17 →	+3.956	+0.092	<.001	.001	3	7
LARGE_INTESTINE	SCARA3 →	+1.890	+0.083	<.001	<.001	3	7
LARGE_INTESTINE	BCAM →	+1.939	+0.083	<.001	<.001	3	7
OVARY	HAPLN3 →	+1.618	+0.064	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902229 vs LAMB3 — BREAST

Explore this scatter interactively →