Regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HJURP, EPCAM, and CSGALNACT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to DNA damage activity versus HJURP in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HJURP →	+0.823	+0.214	.003	<.001	3	6
URINARY_TRACT	EPCAM →	-5.609	-0.364	.001	.009	3	5
URINARY_TRACT	CSGALNACT2 →	+1.170	+0.373	.001	.006	3	5
LUNG_SCLC	ZC3H13 →	+0.478	+0.205	.004	.002	3	5
LUNG_SCLC	TDRD7 →	-1.172	-0.235	<.001	.004	3	5
SOFT_TISSUE	DCAF5 →	-1.362	-0.651	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902229 vs HJURP — BLOOD_Lymphoma

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