Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A8, ARHGEF1, and ITGAM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity versus S100A8 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A8 →	+1.665	+0.084	<.001	<.001	3	7
GBM	ARHGEF1 →	+0.219	+0.096	<.001	<.001	3	7
GBM	ITGAM →	+0.999	+0.163	<.001	<.001	3	7
BRCA	S100A9_T113 →	+1.076	+0.068	.004	.006	3	6
GBM	UNC13D →	+0.491	+0.131	<.001	.001	3	6
GBM	CAMP →	+2.074	+0.108	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902219 vs S100A8 — BRCA

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