Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TINF2, SMIM14, and POLK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TINF2 grouped by Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TINF2 →	-0.676	-1.291	<.001	<.001	3	5
LIVER	SMIM14 →	-1.411	-1.234	.005	.005	3	5
CNS	POLK →	-0.597	-1.262	<.001	<.001	3	4
CNS	COL1A2 →	-4.475	-1.052	.005	.001	3	4
OVARY	FKBP7 →	-1.737	-1.207	.001	.006	3	4
PANCREAS	GTF2IRD2 →	-1.034	-1.729	.008	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TINF2 by Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity — LUNG_NSCLC_LUAD

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