Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE3B, DEK, and ELL3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity versus PDE3B in PANCREAS (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDE3B →	+1.195	+2.202	.005	.008	3	2
LUNG_NSCLC_LUAD	DEK →	+1.206	+0.972	<.001	.003	3	2
LUNG_NSCLC_LUAD	ELL3 →	-2.011	-0.361	.003	.004	3	2
LUNG_NSCLC_LUAD	PRPF38B →	-0.654	-0.705	.004	.004	3	2
URINARY_TRACT	MAGEH1 →	+2.220	+1.944	.005	<.001	3	2
STOMACH	GNG13 →	-0.715	-0.348	.009	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902219 vs PDE3B — PANCREAS

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