Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE2, HSP90B1, and PUS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity versus ADGRE2 in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE2 →	+0.416	+0.158	.002	.006	3	4
PDAC	HSP90B1 →	+0.464	+0.455	<.001	<.001	3	4
PDAC	PUS7 →	+0.392	+0.319	<.001	.008	3	4
UCEC	ARHGEF2 →	+0.484	+0.191	.003	.008	3	4
BRCA	ANP32E →	+1.017	+0.375	.002	.001	3	4
BRCA	PRR15 →	-2.126	-0.420	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902218 vs ADGRE2 — LSCC

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