Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGEH1, DEK, and ELL3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity versus MAGEH1 in URINARY_TRACT (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAGEH1 →	+2.220	+1.944	.005	<.001	3	2
LUNG_NSCLC_LUAD	DEK →	+1.206	+0.972	<.001	.003	3	2
LUNG_NSCLC_LUAD	ELL3 →	-2.011	-0.361	.003	.004	3	2
LUNG_NSCLC_LUAD	PRPF38B →	-0.654	-0.705	.004	.004	3	2
PANCREAS	PDE3B →	+1.195	+2.202	.005	.008	3	2
CNS	VPS29 →	-0.599	-0.467	.006	.004	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902218 vs MAGEH1 — URINARY_TRACT

Explore this scatter interactively →