Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DERL3, SH3D19_S65, and CARMIL2_S1381, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus DERL3 in LSCC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DERL3 →	+0.710	+0.050	<.001	<.001	3	5
LSCC	SH3D19_S65 →	+0.322	+0.034	.009	.001	3	5
LSCC	CARMIL2_S1381 →	+1.074	+0.069	<.001	<.001	3	5
GBM	GNAO1 →	+0.692	+0.050	<.001	<.001	3	5
LSCC	HYI →	+0.272	+0.044	.003	.009	3	5
LSCC	PLCL2_S1113 →	+0.476	+0.038	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902177 vs DERL3 — LSCC

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