Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM234, LYZ, and RPL22L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus TMEM234 in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM234 →	+0.277	+0.067	<.001	.001	3	3
PDAC	LYZ →	+1.067	+0.065	.004	.003	3	3
BRCA	RPL22L1 →	-0.526	-0.095	.009	<.001	3	3
LUAD	KHDRBS2 →	-0.914	-0.111	.005	.001	3	3
PDAC	ECE1 →	+0.346	+0.071	.001	.005	3	2
PDAC	ABHD12B →	-0.216	-0.064	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902177 vs TMEM234 — PDAC

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