Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD1, SFPQ, and MCL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOD1 grouped by Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SOD1 →	-0.631	-0.331	<.001	.001	3	7
BREAST	SFPQ →	-0.373	-0.240	.001	.003	3	5
LUNG_SCLC	MCL1 →	-0.630	-0.251	.008	.006	2	6
STOMACH	PPARGC1B →	+0.185	+0.179	.001	.009	3	4
LUNG_NSCLC_LUSC	TMEM14B →	+0.116	+0.330	.003	.004	3	3
LUNG_NSCLC_LUSC	ADGRL3 →	+0.203	+0.297	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOD1 by Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — LUNG_NSCLC_LUSC

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