Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT3, LAMB3, and ETV5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B4GALNT3 grouped by Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	B4GALNT3 →	+1.595	+0.213	.001	.002	3	5
PANCREAS	LAMB3 →	+2.249	+0.192	.006	.007	2	5
PANCREAS	ETV5 →	-1.422	-0.361	<.001	<.001	3	4
PANCREAS	SMIM24 →	+0.759	+0.221	.001	.001	3	4
BREAST	MROH6 →	+1.621	+0.250	.005	<.001	3	4
LUNG_NSCLC_LUAD	PKN1 →	-0.932	-0.184	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B4GALNT3 by Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — PANCREAS

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