Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC31A2, MRPS9, and NUDT12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus SLC31A2 in BLOOD_Myeloma (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC31A2 →	-1.178	-0.391	.009	.002	2	6
BREAST	MRPS9 →	+0.612	+0.152	.008	<.001	3	5
SOFT_TISSUE	NUDT12 →	-0.592	-0.175	<.001	.005	3	4
OVARY	CCNK →	-0.649	-0.117	.001	.007	3	4
CNS	CREB3L2 →	-0.800	-0.121	<.001	.002	3	4
PANCREAS	GTPBP8 →	-0.554	-0.171	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902177 vs SLC31A2 — BLOOD_Myeloma

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