Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS19, RAB23, and SALL2_S804, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus RPS19 in CCRCC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS19 →	-0.151	-0.039	<.001	<.001	3	6
GBM	RAB23 →	+0.363	+0.036	.001	.001	3	5
LSCC	SALL2_S804 →	+0.740	+0.060	<.001	<.001	3	5
LSCC	SFRP2 →	+0.475	+0.026	.003	.005	3	5
LSCC	CTHRC1 →	+0.810	+0.051	<.001	<.001	3	5
LSCC	FNDC3A_S203 →	-0.443	-0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902176 vs RPS19 — CCRCC

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