Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL3, TRBV7-3, and IGHD6-19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus NOL3 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NOL3 →	+0.667	+0.145	.007	.008	3	4
HNSC	TRBV7-3 →	-0.695	-0.174	.002	<.001	3	4
COAD	IGHD6-19 →	-0.784	-0.126	.002	<.001	3	4
LUAD	TESK1 →	+0.281	+0.110	.002	.004	3	3
LSCC	CLEC2B →	+0.618	+0.161	.004	<.001	3	3
PDAC	CRTAP →	+0.329	+0.142	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902176 vs NOL3 — CCRCC

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