Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP12A, MAPKAPK3, and PCDHB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP12A grouped by Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP12A →	+0.371	+0.155	.003	.003	3	5
SOFT_TISSUE	MAPKAPK3 →	+0.186	+0.098	.006	.002	3	4
OVARY	PCDHB6 →	+0.219	+0.068	.003	.009	3	4
OESOPHAGUS	TMEM184B →	-0.157	-0.107	.001	.002	3	4
LUNG_SCLC	KLK11 →	+0.263	+0.163	.002	.002	3	4
BLOOD_Lymphoma	NCALD →	+0.480	+0.127	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP12A by Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — LUNG_SCLC

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