Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD46, B4GALT1, and IFNGR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus CD46 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CD46 →	+1.134	+0.296	<.001	.001	3	6
OESOPHAGUS	B4GALT1 →	+1.354	+0.172	.002	.004	3	5
BLOOD_Leukemia	IFNGR1 →	+0.657	+0.152	.008	.002	2	6
LIVER	FNDC3B →	+1.975	+0.310	.002	<.001	3	5
LIVER	SCARB2 →	+0.835	+0.295	.005	.001	3	5
CNS	LMBRD1 →	+0.675	+0.171	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902176 vs CD46 — LIVER

Explore this scatter interactively →