Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHNAK_S2836, DPYSL3, and ATL1_S23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus AHNAK_S2836 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AHNAK_S2836 →	+0.557	+0.036	.002	.001	3	6
COAD	DPYSL3 →	+0.541	+0.021	.002	.001	3	6
GBM	ATL1_S23 →	+0.747	+0.045	<.001	<.001	3	5
CCRCC	EEF2_S502 →	-0.627	-0.046	<.001	<.001	3	5
HNSC	THRAP3_S55 →	-0.428	-0.068	<.001	.006	3	5
BRCA	UCHL1 →	+0.961	+0.029	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902175 vs AHNAK_S2836 — GBM

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