Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACK1, APC2, and NR2E3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RACK1 grouped by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RACK1 →	-0.379	-0.234	<.001	<.001	2	7
PANCREAS	APC2 →	+0.353	+0.249	.001	.008	3	5
LARGE_INTESTINE	NR2E3 →	-0.193	-0.224	.004	.007	3	5
LUNG_NSCLC_LUAD	NUDT5 →	+0.104	+0.124	.004	.002	3	4
BLOOD_Lymphoma	DRAM2 →	+0.430	+0.182	<.001	<.001	3	4
LUNG_SCLC	ITGA1 →	+0.196	+0.198	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RACK1 by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — OVARY

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