Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF449, CEP85L, and MSRB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF449 grouped by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF449 →	-0.617	-0.230	.003	.003	3	5
LARGE_INTESTINE	CEP85L →	-0.544	-0.187	.007	.006	3	4
STOMACH	MSRB3 →	-2.218	-0.183	.004	.001	3	4
LARGE_INTESTINE	SH2D2A →	+1.190	+0.228	.001	.004	3	4
LARGE_INTESTINE	FLT3LG →	-0.784	-0.175	.003	.001	3	4
PANCREAS	CCDC88C →	+1.553	+0.288	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF449 by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — PANCREAS

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