Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF92, ADSL, and ARNTL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF92 grouped by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF92 →	+0.206	+0.108	<.001	.001	3	4
BLOOD_Myeloma	ADSL →	-0.438	-0.069	.008	.002	2	5
BLOOD_Leukemia	ARNTL2 →	+0.167	+0.115	.001	<.001	3	4
LUNG_NSCLC_LUSC	CDH6 →	-0.195	-0.093	.007	.001	3	4
OVARY	ECM2 →	-0.250	-0.073	.005	.007	3	4
BLOOD_Leukemia	PRDM4 →	+0.280	+0.115	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF92 by Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — OESOPHAGUS

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