Cellular response to reactive nitrogen species

Across TCGA cell cohorts, RNA activity of the Cellular response to reactive nitrogen species pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXD3, MCUB, and TUBB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to reactive nitrogen species activity versus MXD3 in BLOOD_Leukemia (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MXD3 →	-1.434	-0.149	<.001	<.001	3	6
LARGE_INTESTINE	MCUB →	-1.430	-0.233	<.001	<.001	3	6
BLOOD_Myeloma	TUBB →	-0.935	-0.194	.008	.004	3	5
BLOOD_Leukemia	PTTG1 →	-0.896	-0.150	<.001	.001	3	5
BLOOD_Leukemia	E2F7 →	-1.620	-0.151	.001	.003	3	5
LARGE_INTESTINE	ANKRD50 →	-1.354	-0.242	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902170 vs MXD3 — BLOOD_Leukemia

Explore this scatter interactively →