Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF619, EFCAB11, and POC1B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity versus ZNF619 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF619 →	+0.521	+0.181	<.001	.003	3	4
BRCA	EFCAB11 →	+0.398	+0.172	.004	.004	3	4
BRCA	POC1B-AS1 →	+0.344	+0.213	.005	.001	3	4
LUAD	PPP1R14C →	-0.977	-0.245	<.001	<.001	3	4
LSCC	DCTN4 →	+0.376	+0.152	<.001	.002	3	4
BRCA	DTX4 →	-0.759	-0.195	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902165 vs ZNF619 — HNSC

Explore this scatter interactively →