Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC29A1, EMILIN2, and FRMD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC29A1 grouped by Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC29A1 →	+1.068	+0.644	.003	.006	3	3
LARGE_INTESTINE	EMILIN2 →	+1.483	+1.098	.002	.001	3	3
LARGE_INTESTINE	FRMD3 →	+1.461	+0.860	.005	.003	3	3
LARGE_INTESTINE	RAB37 →	+1.078	+1.023	<.001	<.001	3	3
LARGE_INTESTINE	SAMD5 →	+2.227	+0.946	<.001	<.001	3	3
CNS	ENO3 →	+1.339	+1.010	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC29A1 by Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity — BLOOD_Leukemia

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