Negative regulation of organelle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of organelle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL2, SH2D3A, and TARBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELL2 grouped by Negative regulation of organelle assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ELL2 →	-1.425	-0.332	.007	.001	3	4
LIVER	SH2D3A →	+1.649	+0.261	.001	.001	3	4
LIVER	TARBP1 →	+0.904	+0.270	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NTN1 →	+2.393	+0.312	.008	<.001	3	4
OVARY	ZNF552 →	+1.176	+0.289	<.001	<.001	3	4
SKIN	NDRG2 →	+0.732	+0.258	.008	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELL2 by Negative regulation of organelle assembly activity — LIVER

Explore this box plot interactively →