Negative regulation of organelle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of organelle assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA2, HIVEP1, and AHDC1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organelle assembly activity versus GOLGA2 in URINARY_TRACT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GOLGA2 →	+0.879	+0.072	.002	.002	3	19
BLOOD_Lymphoma	HIVEP1 →	+1.179	+0.038	<.001	.001	3	18
SOFT_TISSUE	AHDC1 →	+1.555	+0.087	<.001	<.001	3	17
LUNG_NSCLC_LUSC	LUZP1 →	+1.291	+0.107	<.001	<.001	3	17
URINARY_TRACT	ZNF417 →	+1.225	+0.071	.001	.003	3	17
LARGE_INTESTINE	KATNIP →	+0.968	+0.052	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902116 vs GOLGA2 — URINARY_TRACT

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