Negative regulation of organelle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of organelle assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFOD2, GULP1, and SNU13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organelle assembly activity versus GFOD2 in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GFOD2 →	+0.595	+0.279	.001	.006	3	6
UPPER_AERODIGESTIVE_TRACT	GULP1 →	+2.418	+0.260	<.001	.002	3	5
LARGE_INTESTINE	SNU13 →	+0.473	+0.186	.006	.001	3	5
PANCREAS	DTD2 →	+1.208	+0.360	<.001	.004	3	5
PANCREAS	GINS3 →	+1.311	+0.365	.005	.003	3	5
OVARY	PHLDA2 →	+2.319	+0.308	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902116 vs GFOD2 — SOFT_TISSUE

Explore this scatter interactively →