Regulation of organelle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of organelle assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMI, PRKAR1A, and CST3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMI grouped by Regulation of organelle assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NMI →	+0.619	+0.164	.004	<.001	3	5
LARGE_INTESTINE	PRKAR1A →	-0.667	-0.123	<.001	.002	3	4
BLOOD_Myeloma	CST3 →	+2.796	+0.148	.001	.001	3	4
STOMACH	NMT1 →	+0.663	+0.187	.005	.005	3	4
CNS	ABI2 →	-0.661	-0.137	<.001	.006	3	4
LUNG_NSCLC_LUSC	C1orf53 →	+0.758	+0.138	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMI by Regulation of organelle assembly activity — PANCREAS

Explore this box plot interactively →