Regulation of mitochondrial membrane permeability involved in apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial membrane permeability involved in apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THRAP3_S253, C12orf75, and POLRMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane permeability involved in apoptotic process activity versus THRAP3_S253 in UCEC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THRAP3_S253 →	-0.299	-0.040	.006	.008	3	4
OV	C12orf75 →	+0.345	+0.031	<.001	<.001	3	4
LSCC	POLRMT →	-0.380	-0.033	.007	.005	3	4
GBM	BASP1 →	+0.630	+0.030	<.001	.007	3	4
COAD	SPAG9 →	-0.165	-0.019	.001	.004	2	5
LUAD	SLTM_S421 →	+0.782	+0.036	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902108 vs THRAP3_S253 — UCEC

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