Regulation of mitochondrial membrane permeability involved in apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane permeability involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSBP1L1, C12orf42, and SETX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSBP1L1 grouped by Regulation of mitochondrial membrane permeability involved in apoptotic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HSBP1L1 →	-2.270	-1.238	.007	.006	3	4
LUNG_NSCLC_LUAD	C12orf42 →	-0.122	-0.728	.005	.003	3	4
LUNG_SCLC	SETX →	-0.775	-0.804	<.001	.001	3	4
LARGE_INTESTINE	YRDC →	+0.628	+0.770	.005	.009	3	4
CNS	DDB2 →	-1.466	-1.123	<.001	<.001	3	4
SOFT_TISSUE	KIFAP3 →	-1.732	-1.464	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSBP1L1 by Regulation of mitochondrial membrane permeability involved in apoptotic process activity — BLOOD_Myeloma

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