Regulation of mitochondrial membrane permeability involved in apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane permeability involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKL3, RABL3, and SNAPC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane permeability involved in apoptotic process activity versus CDKL3 in SOFT_TISSUE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CDKL3 →	+0.964	+0.251	.003	.002	3	5
LUNG_NSCLC_LUSC	RABL3 →	-1.082	-0.368	.003	.004	3	4
LUNG_NSCLC_LUSC	SNAPC1 →	-2.014	-0.371	.004	.006	3	4
BREAST	PSRC1 →	-1.046	-0.292	.005	.002	3	4
KIDNEY	NPM1 →	-0.969	-0.264	.004	<.001	3	4
BREAST	MT-ND3 →	+0.942	+0.326	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902108 vs CDKL3 — SOFT_TISSUE

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