Positive regulation of metaphase/anaphase transition of cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of metaphase/anaphase transition of cell cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPP14, ZNF785, and SH2D6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPP14 grouped by Positive regulation of metaphase/anaphase transition of cell cycle-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPP14 →	+0.175	+0.398	.001	.009	3	4
BONE	ZNF785 →	+0.436	+0.532	.006	.008	2	4
SKIN	SH2D6 →	+0.128	+0.342	<.001	<.001	3	3
SKIN	WDR41 →	+0.181	+0.375	<.001	.008	2	4
SKIN	ZFAND4 →	-0.163	-0.419	<.001	.001	3	3
BLOOD_Leukemia	KMT2C →	+0.202	+0.361	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPP14 by Positive regulation of metaphase/anaphase transition of cell cycle activity — CNS

Explore this box plot interactively →