Cellular response to salt

Across TCGA cell cohorts, RNA activity of the Cellular response to salt pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRXN1, CYP2S1, and MYOC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRXN1 grouped by Cellular response to salt-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SRXN1 →	-1.105	-0.337	.001	<.001	3	3
KIDNEY	CYP2S1 →	-1.441	-0.668	.007	.005	3	3
KIDNEY	MYOC →	-0.064	-1.134	.001	<.001	3	3
KIDNEY	OSGEP →	-0.593	-0.639	.001	.008	3	3
BONE	IGFBP4 →	-2.466	-0.224	.001	<.001	3	3
BONE	HSPA1L →	-0.408	-0.211	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRXN1 by Cellular response to salt activity — BLOOD_Myeloma

Explore this box plot interactively →