Response to L-glutamate

Across TCGA patient cohorts, RNA activity of the Response to L-glutamate pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX2, PCDH7, and MMP19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-glutamate activity versus RUNX2 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RUNX2 →	-0.510	-0.577	.001	.007	3	4
HNSC	PCDH7 →	-1.002	-0.510	.002	.005	3	4
BRCA	MMP19 →	-0.722	-0.550	<.001	.001	3	4
BRCA	GFPT2 →	-0.619	-0.517	<.001	<.001	3	4
BRCA	MYO1E →	-0.442	-0.537	<.001	<.001	3	4
BRCA	COL3A1 →	-1.035	-0.542	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902065 vs RUNX2 — LSCC

Explore this scatter interactively →