Response to L-glutamate

Across TCGA cell cohorts, RNA activity of the Response to L-glutamate pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPA, NPC1, and RSL24D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIRPA grouped by Response to L-glutamate-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIRPA →	-2.389	-0.209	<.001	.003	3	4
CNS	NPC1 →	-1.505	-1.030	<.001	<.001	3	4
SKIN	RSL24D1 →	+0.898	+1.359	.001	<.001	3	4
OESOPHAGUS	PSMC6 →	+0.798	+0.201	.009	.005	3	3
SKIN	CLCN7 →	-1.142	-0.914	<.001	.003	3	3
OESOPHAGUS	PLOD3 →	-1.286	-0.161	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIRPA by Response to L-glutamate activity — OESOPHAGUS

Explore this box plot interactively →