Regulation of Fas signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of Fas signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR23A, SP100, and MIR27A, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Fas signaling pathway activity versus MIR23A in CHOL (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	MIR23A →	-1.813	-0.111	<.001	<.001	2	26
PCPG	SP100 →	+0.766	+0.039	<.001	<.001	3	25
READ	MIR27A →	-1.077	-0.077	<.001	<.001	3	24
UVM	APOL6 →	+1.806	+0.058	<.001	.001	3	23
SKCM	SP110 →	+0.626	+0.069	<.001	<.001	3	21
UCS	OAS2 →	+1.361	+0.069	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902044 vs MIR23A — CHOL

Explore this scatter interactively →