Regulation of Fas signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of Fas signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, ZDHHC21, and SOCS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Fas signaling pathway activity versus B2M in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	B2M →	+0.580	+0.534	<.001	<.001	3	6
LUAD	ZDHHC21 →	-0.582	-0.274	.002	.002	3	5
GBM	SOCS7 →	-0.423	-0.631	<.001	<.001	3	5
LSCC	ADNP2 →	-0.503	-0.261	<.001	<.001	3	5
GBM	PANK3 →	-0.591	-0.773	<.001	<.001	3	5
LSCC	CXXC1 →	-0.530	-0.296	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902044 vs B2M — GBM

Explore this scatter interactively →