Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2, PPP1R18_S224, and BTK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus THEMIS2 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THEMIS2 →	+0.502	+0.036	<.001	.002	3	8
PDAC	PPP1R18_S224 →	+0.470	+0.061	<.001	<.001	3	8
BRCA	BTK →	+0.452	+0.035	<.001	.004	3	7
BRCA	DDAH1 →	-0.679	-0.039	<.001	<.001	2	8
GBM	DNAJC13 →	+0.187	+0.064	<.001	<.001	3	7
GBM	FAP →	+0.803	+0.065	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902042 vs THEMIS2 — BRCA

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