Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPOCD1, MRC2, and TSHZ3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus SPOCD1 in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SPOCD1 →	+0.752	+1.004	<.001	<.001	3	6
COAD	MRC2 →	+0.749	+0.652	.002	.005	3	5
LSCC	TSHZ3 →	+0.457	+0.191	.008	.006	3	5
LSCC	SIGLEC9 →	+0.501	+0.238	<.001	.008	3	5
BRCA	SLC43A3 →	+0.763	+0.133	<.001	<.001	3	5
LSCC	ADAMTS4 →	+0.819	+0.239	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902042 vs SPOCD1 — COAD

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