Regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPSTI1, RTP4, and GIMAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPSTI1 grouped by Regulation of extrinsic apoptotic signaling pathway via death domain receptors-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EPSTI1 →	+1.898	+0.689	<.001	.004	3	5
PANCREAS	RTP4 →	+1.355	+0.665	.002	.006	3	4
LARGE_INTESTINE	GIMAP2 →	+1.597	+0.634	<.001	.009	3	4
LARGE_INTESTINE	AREG →	+2.998	+1.099	.009	.002	3	4
BLOOD_Leukemia	SLK →	+1.242	+1.029	.001	.008	3	4
BLOOD_Leukemia	TMED2 →	+0.781	+1.468	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPSTI1 by Regulation of extrinsic apoptotic signaling pathway via death domain receptors activity — PANCREAS

Explore this box plot interactively →