Regulation of hematopoietic stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A3R1_S269, SYNRG, and BCAS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell differentiation activity versus SLC9A3R1_S269 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC9A3R1_S269 →	-1.121	-0.064	.008	.001	3	4
CCRCC	SYNRG →	-0.153	-0.035	<.001	<.001	3	4
BRCA	BCAS1 →	-0.930	-0.038	<.001	<.001	3	4
LUAD	CENPF_S3023 →	+0.968	+0.034	.001	.002	3	4
LUAD	MSH2 →	+0.244	+0.037	.005	.004	2	5
BRCA	PUS7 →	+0.472	+0.036	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902036 vs SLC9A3R1_S269 — OV

Explore this scatter interactively →